If this variable is set globally (or on a per-user basis), the system will search for libraries in locations specified by LD_LIBRARY_PATH first. This will slow down application loading times and can particularly affect GUI sessions.
LD_LIBRARY_PATH should only be set on a per-application basis like this:
$ LD_LIBRARY_PATH=/tool/bin some_dependent_program
You can also try to disable SELinux in your system