In the case of a circuit with a wire that is missing, a message such as the following can appear in the Simulation/Synthesis Messages window during a simulation:
Warning detected by HPEESOFSIM during DC analysis "DC1".
Circuit as given has no unique solution.
A virtual resistance of 1 TOhms was added to each node.
In the case of unconnected wires or pins, choose Tools
> Check Representation, then select Open connections
and click OK. All unconnected wires and components are highlighted, making them easily visible on the screen. Connect these to the correct circuit node.